The pharmacokinetics of ceftriaxone in serum, skin blister and thread fluid

Abstract

Following 4 g of ceftriaxone, given intravenously, to eight volunteers, the antibiotic concentration in serum, suction skin blister fluid and fluid from subcuta-neously implanted threads was followed for 28 h. High and sustained levels were found in both serum and extravascular fluids; the mean maximum serum concentration was 448 mg/1, and the mean peak concentrations in blister and thread fluid were 94 mg/l and 63 mg/l, respectively. The terminal, half-lives were: serum 7.2 h, blister fluid 10.3 h and thread fluid 11.3 h. The total area under the concentration versus time curves for serum was 1636 mg.h/l. For blister and thread fluid the areas were 1573 mg.;h/l and 808 mg.h/l. The results suggest a twice daily dosage regimen.