Algorithms to predict cerebral malaria in murine models using the SHIRPA protocol
Open Access
- 24 March 2010
- journal article
- Published by Springer Nature in Malaria Journal
- Vol. 9 (1), 85
- https://doi.org/10.1186/1475-2875-9-85
Abstract
Plasmodium berghei ANKA infection in C57Bl/6 mice induces cerebral malaria (CM), which reproduces, to a large extent, the pathological features of human CM. However, experimental CM incidence is variable (50-100%) and the period of incidence may present a range as wide as 6-12 days post-infection. The poor predictability of which and when infected mice will develop CM can make it difficult to determine the causal relationship of early pathological changes and outcome. With the purpose of contributing to solving these problems, algorithms for CM prediction were built.Keywords
This publication has 42 references indexed in Scilit:
- Murine Cerebral Malaria Is Associated with a Vasospasm-Like Microcirculatory Dysfunction, and Survival upon Rescue Treatment Is Markedly Increased by NimodipineThe American Journal of Pathology, 2010
- Characterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKAInternational Journal of Experimental Pathology, 2009
- Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory studyPhysiological Genomics, 2008
- Cerebral Malaria in Children Is Associated With Long-term Cognitive ImpairmentPediatrics, 2008
- Chapter 1 Strain Theory of MalariaAdvances in Parasitology, 2008
- Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of diseaseThe Journal of Experimental Medicine, 2008
- Radiolabeled Melanin-Binding Peptides Are Safe and Effective in Treatment of Human Pigmented Melanoma in a Mouse Model of DiseaseCancer Biotherapy & Radiopharmaceuticals, 2006
- The origins and uses of mouse outbred stocksNature Genetics, 2005
- Malaria parasitemia in healthy Africans in North Mara, TanzaniaJournal of Community Health, 1986
- Cerebral malaria in inbred mice. I. A new model and its pathologyTransactions of the Royal Society of Tropical Medicine and Hygiene, 1982