Linkage detection by the Affected‐Pedigree‐Member method: What is really tested?
- 1 January 1993
- journal article
- research article
- Published by Wiley in Genetic Epidemiology
- Vol. 10 (6), 389-394
- https://doi.org/10.1002/gepi.1370100610
Abstract
We show that the null hypothesis in the Affected-Pedigree-Member (APM) method is composed of two sub-hypotheses: no linkage and correct marker allele distribution. As a result, the APM method is not robust to misspecification of marker allele frequencies.Keywords
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