Preimplantation Diagnosis for Fanconi Anemia Combined With HLA Matching

Abstract

Preimplantation genetic diagnosis (PGD) was introduced for couples at high risk for producing progeny with genetic disorders to avoid prenatal diagnosis followed by pregnancy termination.^1,2 Preimplantation genetic diagnosis has become an alternative to traditional prenatal genetic diagnosis and also an integral part of assisted reproduction, providing an important tool for improving the efficiency of in vitro fertilization (IVF) through avoiding the transfer of aneuploid embryos.^3,4 Preimplantation genetic diagnosis has been performed in more than 2500 clinical cycles for at-risk couples, resulting in approximately 600 clinical pregnancies and births of at least 500 healthy children.^5-10