Charybdotoxin blocks dendrotoxin‐sensitive voltage‐activated K+ channels
- 3 July 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 250 (2), 519-522
- https://doi.org/10.1016/0014-5793(89)80788-4
Abstract
Charybdotoxin, a short scorpion venom neurotoxin, which was thought to be specific for the blockade of Ca2+-activated K+ channels also blocks a class of voltage-sensitive K+ channels that are known to be the target of other peptide neurotoxins from snake and bee venoms such as dendrotoxin and MCD peptide. Charybdotoxin also inhibits 125-dendrotoxin and 125I-MCD peptide binding to their receptors. All these effects are observed with an IC50 of about 30 nMKeywords
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