Some factors influencing the anticoagulant action of heparin

Abstract

Prolonged dialysis of plasma has little effect on the antithrombin activity of heparin. Addition of NaCl to this plasma decreases the activity of the heparin. The results of Howell which indicated that heparin is only active in the presence of a protein in plasma are confirmed. The protein is found in the albumin fraction but is not crystalline serum albumin.