Thioglycollate Inactivation of Posterior Pituitary Antidiuretic Principle as Determined in the Rat.

Abstract

After intraperit. or sub-cut. injn., an aqueous soln. of Na thioglycollate markedly reduces water diuresis in rats and cannot be used by either route to demonstrate unequivocally whether posterior pituitary anti- diuretic principle has been inactivated. By the intraven. route in rats, thioglycollate does not interfere with diuresis and can be shown, as in the dog, to abolish the antidiuretic action of pitressin. Therefore, there is no controlled exptl. evidence that pitressin contains more than one antidiuretic principle.