Influence of Genes Associated with the Main Histocompatibility Complex on Deoxyribonucleic Acid Excision Repair Capacity and Bleomycin Sensitivity in Mouse Lymphocytes
- 11 December 2008
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 14 (4), 336-342
- https://doi.org/10.1111/j.1399-0039.1979.tb00858.x
Abstract
In sets of mice (C57BL/10, B10.AKM B10.BR, C3H.SW and C3H/He) congenic at H-2 (major histocompatibility complex) and 2 backgrounds, and selected according to known differences in strain-specific lifespans, DNA repair efficiency in spleen cells was compared by 2 techniques: excision repair capacity following UV-irradiation, and bleomycin sensitivity. Significant differences between certain congenic partner sets were noted with both techniques, suggesting that the main histocompatibility complex influences DNA repair capacity.This publication has 23 references indexed in Scilit:
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