Cell density and cortex thickness in the border zone surrounding old infarcts in the human brain.
- 1 November 1984
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 15 (6), 1033-1039
- https://doi.org/10.1161/01.str.15.6.1033
Abstract
Six [autopsy] cases of completed ischemic stroke in the middle cerebral territory of > 2 mo. duration were selected for this study of neuropathology. Coronal brain slices of the entire brain were cut for histology and stained with Kluver-Barrera''s stain. Neuronal and glial cell density, and cortex thickness were measured at various distances from the border of the infarct. Corresponding counting points in the contralateral hemisphere served as control in all cases. The density of histologically intact neurons was in all cases normal at a distance of .gtoreq. 0.5 cm from the border of the infarcts. In one half of the cases the border zone between infarcted and normal tissue was less than a few cells in thickness. There evidently is an abrupt transition between infarcted and normal tissue. The wide zone of low blood flow and metabolism surrounding cerebral infarcts is not caused by selective loss of neurons. Such change in blood flow and metabolism could be the result of neuronal disconnection and cortical deactivation.This publication has 10 references indexed in Scilit:
- Blood flow and vascular reactivity in collaterally perfused brain tissue. Evidence of an ischemic penumbra in patients with acute stroke.Stroke, 1983
- SERIAL OBSERVATIONS ON THE PATHOPHYSIOLOGY OF ACUTE STROKEBrain, 1983
- The Cortical Ischaemic Penumbra Associated with Occlusion of the Middle Cerebral Artery in the Cat: 2. Studies of Histopathology, Water Content, and in vitro Neurotransmitter UptakeJournal of Cerebral Blood Flow & Metabolism, 1983
- The Cortical Ischaemic Penumbra Associated with Occlusion of the Middle Cerebral Artery in the Cat: 1. Topography of Changes in Blood Flow, Potassium Ion Activity, and EEGJournal of Cerebral Blood Flow & Metabolism, 1983
- Flow and neuronal density in tissue surrounding chronic infarction.Stroke, 1983
- Transient Focal Ischemia in Subhuman PrimatesJournal of Neuropathology and Experimental Neurology, 1983
- Cerebral Oxygen Metabolism and Blood Flow in Human Cerebral Ischemic InfarctionJournal of Cerebral Blood Flow & Metabolism, 1982
- Thresholds of focal cerebral ischemia in awake monkeysJournal of Neurosurgery, 1981
- Effects of stroke on local cerebral metabolism and perfusion: Mapping by emission computed tomography of 18FDG and 13NH3Annals of Neurology, 1980
- Extracellular potassium activity, evoked potential and tissue blood flowJournal of the Neurological Sciences, 1977