There Are GAPS and There Are GAPS
- 3 January 1997
- journal article
- perspective
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 275 (5296), 42-43
- https://doi.org/10.1126/science.275.5296.42
Abstract
Guanine nucleotide-binding proteins (G proteins) transduce a very large number of cellular regulatory signals. Several recent papers have shown that the larger heterotrimeric G proteins are regulated by a class of molecules known as the RGS proteins (regulators of G protein-signaling family) that are analogous to the GAPs (GTPase activating proteins), which regulate small monomeric G proteins. Iyengar summarizes this evidence and discusses the mechanism of action of the RGS proteins.Keywords
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