Strategies for cancer gene therapy
- 22 December 2003
- journal article
- review article
- Published by Wiley in Journal of Surgical Oncology
- Vol. 85 (1), 28-35
- https://doi.org/10.1002/jso.20001
Abstract
Gene therapy offers new opportunities for cancer treatment and prevention through the use of targeted, relatively nontoxic treatments that can identify, disable, and destroy malignant cells. This article reviews the principles behind oncogene inactivation, tumor suppressor gene replacement, inhibition of angiogenesis, immunopotentiation, molecular chemotherapy, and addition of drug resistance genes. The adcantages and limitations of viral and nonviral vectors for delivery of the therapeutic genes are presented. J. Surg. Oncol. 2004;85:28–35.Keywords
This publication has 83 references indexed in Scilit:
- Adenovirus-mediated gene transfer of P16INK4/CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivoCancer Gene Therapy, 2002
- Adeno-associated virus–mediated gene transfer of endostatin inhibits angiogenesis and tumor growth in vivoCancer Gene Therapy, 2002
- Genetic protection of repopulating hematopoietic cells with an improved MDR1‐retrovirus allows administration of intensified chemotherapy following stem cell transplantation in miceInternational Journal of Cancer, 2002
- Gene transfer of antisense hypoxia inducible factor-1 α enhances the therapeutic efficacy of cancer immunotherapyGene Therapy, 2001
- pRb2/p130 Gene Overexpression Induces Astrocyte DifferentiationMolecular and Cellular Neuroscience, 2001
- c‐fos Protooncogene Transcription can be Modulated by Oligonucleotide‐Mediated Formation of Triplex Structures in vitroEuropean Journal of Biochemistry, 1996
- HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulatorCell, 1995
- Inhibition of in Vitro Transcription by a Triplex-Forming Oligonucleotide Targeted to Human c-myc P2 PromoterBiochemistry, 1995
- Circumvention of chemotherapy-induced myelosuppression by transfer of themdr1 geneBiotherapy, 1993
- Triplex formation inhibits HER-2/neu transcription in vitro.Journal of Clinical Investigation, 1993