Indirect Method for Assessing the Penetration of Beta-Lactamase-Nonsusceptible Penicillins and Cephalosporins in Escherichia coli Strains
- 1 August 1976
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 10 (2), 215-218
- https://doi.org/10.1128/aac.10.2.215
Abstract
Escherichia coli UB1005 and two mutants of this strain (DC2 and DC3) have been used to assess indirectly the relative ability of various β-lactam antibiotics to penetrate the outer layers of E. coli . Benzylpenicillin, ampicillin, methicillin, cloxacillin, cephaloridine, cephalothin, and cephalexin have been examined. The results confirm those obtained with other methods and show that, among the compounds studied here, cephalosporins seem to penetrate more readily than penicillins.Keywords
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