Preliminary Observations on the Effect of Mantle Field Radiotherapy on Salivary Flow Rates in Patients with Hodgkin's Disease
- 1 February 1988
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 67 (2), 518-521
- https://doi.org/10.1177/00220345880670021801
Abstract
Changes in stimulated and non-stimulated whole saliva flow rates were measured in 11 Hodgkin's disease patients who received therapeutic doses of radiation to a mantle field at the M. D. Anderson Hospital in Houston, Texas. Salivary flow rates were examined before, during, and after radiotherapy. Mean flow rate reductions of 54% for non-stimulated saliva and 55.7% for paraffin-stimulated saliva were observed post-radiotherapy. Flow rates had not returned to pre-irradiation levels in any of the patients who were observed for two to three months after completion of therapy. Results obtained from this preliminary study indicate that most patients who receive therapeutic doses of radiation to a mantle field experience a significant reduction in salivary output which is manifest during the period of treatment and persists for a period of at least two to three months post-radiotherapy.This publication has 10 references indexed in Scilit:
- Iatrogenic Causes of Salivary Gland DysfunctionJournal of Dental Research, 1987
- Physiological Factors Affecting Salivary Flow Rate, Oral Sugar Clearance, and the Sensation of Dry Mouth in ManJournal of Dental Research, 1987
- Mantle irradiation of the major salivary glandsThe Journal of Prosthetic Dentistry, 1985
- Effects of Radiotherapy on Human Parotid SalivaRadiation Research, 1981
- Parotid gland pathophysiology after mixed gamma and neutron irradiation of cancer patientsOral Surgery, Oral Medicine, Oral Pathology, 1981
- Some factors influencing salivary function when treating with radiotherapyInternational Journal of Radiation Oncology*Biology*Physics, 1981
- Alterations in whole saliva flow rate induced by fractionated radiotherapyAmerican Journal of Roentgenology, 1978
- Radiation-induced xerostomia in cancer patients.Effect on salivary and serum electrolytesCancer, 1976
- Salivary Sodium, Potassium, and Chloride Levels in Subjects Classified as to Dental Caries ExperienceJournal of Dental Research, 1958