The molecular basis of DNA–protein recognition inferred from the structure of cro repressor
- 31 July 1982
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 298 (5876), 718-723
- https://doi.org/10.1038/298718a0
Abstract
Recognition by cro repressor protein from phage .lambda. of its specific DNA binding sites appears to occur via multidentate H bonds between amino acid side chains of the protein and base-pair atoms in the major groove of right-handed B-form DNA. Most of the sequence-specific interactions between cro and DNA, as well as a number of sequence-independent ones, are mediated by a 2-.alpha.-helical unit which appears to be common to many proteins that regulate gene expression.Keywords
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