Use of 18O labels to monitor deamidation during protein and peptide sample processing
- 1 June 2008
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Society for Mass Spectrometry
- Vol. 19 (6), 855-864
- https://doi.org/10.1016/j.jasms.2008.02.011
Abstract
Nonenzymatic deamidation of asparagine residues in proteins generates aspartyl (Asp) and isoaspartyl (isoAsp) residues via a succinimide intermediate in a neutral or basic environment. Electron cap...Keywords
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