Isolation and characterization of the MHC linked β‐type proteasome subunit MC13 cDNA
- 11 May 1992
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 302 (2), 121-125
- https://doi.org/10.1016/0014-5793(92)80420-l
Abstract
We have cloned and analysed the second mouse MHC-linked proteasome subunit, designated MC13, which appears to be homologous to the human RING10 proteasome protein. The isolated cDNA has an ORF encoding a protein of 276 amino acids with a molecular weight of ca. 30 kDa. Sequence: alignment reveals that the subunit MC13 and several other mammalian proteasome subunits are encoded by a second proteasome gene family. This second gene family encodes subunits of the β-type, reveals striking sequence similarities with the β-subunit of archaebacterial proteasomes and is related to, but distinct from, the genes encoding the so-called α-type subunits.Keywords
This publication has 23 references indexed in Scilit:
- Second proteasome-related gene in the human MHC class II regionNature, 1991
- Subunit of the '20S' proteasome (multicatalytic proteinase) encoded by the major histocompatibility complexNature, 1991
- Structural and serological similarity of MHC-linked LMP and proteasome (multicatalytic proteinase) complexesNature, 1991
- A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHCNature, 1991
- The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologousBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1991
- Cloning and sequencing of the gene encoding the large (α‐) subunit of the proteasome from Thermoplasma acidophilumFEBS Letters, 1991
- Cell-specific accumulation of Drosophila proteasomes (MCP) during early development.The Journal of cell biology, 1990
- The multicatalytic proteinase complex, a major extralysosomal proteolytic systemBiochemistry, 1990
- cDNA cloning and sequencing of component C9 of proteasomes from rat hepatoma cellsFEBS Letters, 1990
- Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome)Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1990