Studies on the Cellular Basis for Partial Tolerance: Antigen-Specific Suppression of Antigen-Induced Thymidine-2-14C Incorporation In Vitro

Abstract

The suppression of delayed hypersensitivity by induction of partial immunologic tolerance is antigen-specific both in vivo and in vitro. Lymph node cells from partially tolerant animals incorporate thymidine-2-¹⁴C either poorly or not at all in response to antigenic challenge in vitro. The latter response more closely parallels the diminution of delayed skin reactivity than the decrease in antibody production in partially tolerant animals.