Suppression of Delayed Type Hypersensitivity Induction to Sheep Red Blood Cells by Concanavalin A in Mice
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 54 (2), 158-164
- https://doi.org/10.1159/000231819
Abstract
An examination was carried out on the in vivo effect of concanavalin A (Con A) on the induction of delayed-type hypersensitivity (DTH) to heterologous erythrocytes in mice. DTH induction was suppressed by an intravenous injection of 100 μg of Con A 1 day before, or simultaneously with immunization. This suppression was mediated by Con-A-activated spleen cells, and also by their cell-free extracts. However, this suppressive effect was abrogated by absorption of cell-free extracts with immuno adsorbent composed of rabbit anti-mouse thymocyte serum (ATS), indicating that suppressive factors for DTH induction make up one of the components extractable from Con-A-activated T cell population.Keywords
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