Effects of Bacterial Endotoxin on the Occurrence of Spleen Colonies in Irradiated Mice

Abstract

In mice given a single injection of endotdxin either before or shortly after irradiation, splenic nodules, as well as bone marrow cellularity and survival, were increased over the irradiated controls. The maximum effect was seen with 25 [mu]g given 1 day before irradiation. In mice given a series of injections before irradiation there was a dissociation between the number of splenic nodules, which was increased, and bone marrow recovery and survival, which were essentially the same as in the controls.