The Mechanism of Hypoalbuminemia in Rheumatoid Arthritis
- 1 July 1965
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 63 (1), 109-114
- https://doi.org/10.7326/0003-4819-63-1-109
Abstract
Hypoalbuminemia is frequently encountered in rheumatoid arthritis, but the mechanism producing this abnormality has not previously been investigated. Tracer studies using isotopically labeled human albumin can help towards solving the problem. By measuring albumin turnover with I131-labeled albumin, it can be determined whether the hypoalbuminemia results from decreased synthesis or increased catabolism or if there is an abnormal distribution of the protein. If the turnover rate is increased, then Cr51-labeled albumin can be used to find out if this is due to a protein-losing gastroenteropathy (1). These techniques have been employed to study albumin metabolism in a selected group ofKeywords
This publication has 7 references indexed in Scilit:
- SERUM ALBUMIN TURNOVER IN NORMAL SUBJECTS AND PATIENTS WITH CIRRHOSIS MEASURED BY 131I-LABELLED HUMAN ALBUMIN1963
- STUDIES OF PLASMA PROTEIN METABOLISM .1. ALBUMIN IN BURNED AND INJURED PATIENTS1962
- EFFECT OF MALNUTRITION ON METABOLISM OF PLASMA ALBUMIN1962
- METABOLISM OF 131I LABELLED HUMAN ALBUMIN1961
- THE EFFECT OF CUSHING'S SYNDROME UPON SERUM ALBUMIN METABOLISM *JCI Insight, 1960
- DIFFERENCE IN DAILY ALBUMIN SYNTHESIS BETWEEN NORMAL MEN AND WOMEN AS MEASURED WITH I-131-LABELED ALBUMIN1960
- STUDIES OF IODOALBUMIN METABOLISM. II. THE EFFECTS OF THYROID HORMONE*JCI Insight, 1959