Abstract
Postorchiectomy abdominal irradiation for testicular cancer has become a well established procedure during the last decade. While this is not a common neoplasm, 99 cases have been seen since 1935 at the Tumor Institute of the Swedish Hospital of Seattle (Table I). Of this number, 22 were untreated. Beside 10 seen in consultation, 6 were moribund, in 3 instances even beyond biopsy, and in general susceptible only to pharmacological palliation. Three were seen with widespread metastases, while 2 others refused treatment on religious grounds. The treated cases fall into two groups: those treated prior to 1946 and those seen subsequently (Table II). In the earlier period the practice was orchiectomy, with irradiation only for recurrences and metastases. The more recent picture is good, as cancer goes. The favorable results recorded by Friedman and Moore (1), Milton Friedman (2), and others (3) have influenced our surgeons, since 1946, to call for intensive postoperative irradiation even when no clinical evidence of metastasis could be found. As indicated in Table III, the results of combined surgical and radiological management have supported Friedman's 85 per cent control dictum (2). No correlation between tunica vaginalis or blood vessel invasion and control could be established in this material. Control in embryonal-cell carcinoma and seminoma was essentially the same. In this connection it is to be noted that our material included an unusually high percentage of tumors called embryonal-cell carcinoma as compared to the Army statistics (4), our figure being similar to that of Kaplan et al. (5). For the unfortunate patient with metastases clinically evident at the time of discovery of a primary tumor of the testis, the outlook is grim. But, though grim, it is not hopeless, as evidenced by the 3 cures shown in Table III and by the response of many more to multiple therapeutic procedures, with a gain of months or even years of useful life. As physicians, we are charged with the rehabilitation and care of these patients for varying periods of survival. The seminoma patient whose chest roentgenograms are seen in Figure 1 had a large tumor, a 3D-pound weight loss, and an abdominal mass 18 cm. in diameter at the level of the renal pedicle. The abdominal mass responded so well to irradiation in 1943 that the pelvic fields were treated. In 1944, a mediastinal mass became evident (Fig. 1A) and this was also treated. Since that time the patient has remained disease-free for nine years (Fig. 1B). In another patient with teratoma of the testis and positive inguinal nodes at surgery, an iliac mass palpable above the inguinal ligament following orchiectomy disappeared after 5,000 r irradiation. His subsequent survival for fourteen years includes a tour of mine-sweeping duty along the China coast during World War II.