EFFECT OF STRESS UPON GLYCOSURIA OF FORCE-FED DEPANCREATIZED AND OF ADRENALECTOMIZED-DEPANCREATIZED RATS

Abstract

Male rats which were made mildly diabetic by partial pancreatectomy were force-fed a medium carbohydrate diet. 20 rats -were adrenalectomized and treated with amts. of adrenal cortex extracts which sustained the pre-adrenalectomy level of glycosuria. An equal number of non-adrenalectomized rats were studied in parallel. The subcut. injn. of solns. of 1.5% formaldehyde, in doses of 0.25, 0.5 and 1 cc. twice daily for 7 days, 5 rats per dose level, caused some decrease in the glycosuria of the non-adrenalectomized rats and a much more striking decrease in the glycosuria of the adrenalectomized rats. When the injns. were stopped, the glycosuria was re-established at its pre-injn. level. Five pairs of rats were given 0.25 cc. of 1.5% formaldehyde for 28 days. The decrease in glycosuria which occurred in all of the animals was much more striking in the adrenalectomized rats, but tended to rise towards the pre-stress level before the injns. of formaldehyde were stopped.