Selective Inhibition of Deoxyribonucleic Acid Synthesis by Salicylhydroxamic Acid.

Abstract

Summary Salicylhydroxamic acid (SHA) was shown to be a selective inhibitor of DNA synthesis by Ehrlich ascites tumor cells in vitro. Inhibition was evident virtually immediately after addition of the compound to the cells; no preincubation was necessary to evoke the effect. Cells which were preincu-bated with SHA for up to 2 hours showed only a slight depression of RNA synthesis, while the rate of protein synthesis was unaltered. Reversal of the inhibition upon removal of SHA was complete at lower concentrations, and partial at higher concentrations.