Multi-lineage ‘stem’ cells in the mammalian embryo
- 1 February 1988
- journal article
- review article
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 1988 (Supplement), 11-27
- https://doi.org/10.1242/jcs.1988.supplement_10.2
Abstract
The term ‘stem’ cell has acquired a rather more restricted meaning in cell biology than in embryology as a result of studies on the growth kinetics of renewing tissues in mature organisms. It is normally used in an embryological context as a synonym for ‘progenitor’ cell. Methods of establishing the existence of multi-lineage progenitor cells in mammals are examined briefly before the occurrence and properties of such cells in both embryonic and extra-embryonic tissues of the mouse conceptus are reviewed. Various attributes of ‘stem’ cells that can be obtained from outgrowths of blastocysts in vitro are also discussed.Keywords
This publication has 59 references indexed in Scilit:
- Indeterminate cell lineage of the zebrafish embryoDevelopmental Biology, 1987
- Germline and somatic mosaicism in transgenic miceDevelopmental Biology, 1986
- Isolation and characterization of trophoblast from murine placentaPlacenta, 1986
- Cell fate in the polar trophectoderm of mouse blastocysts as studied by microinjection of cell lineage tracersDevelopmental Biology, 1985
- Potential of isolated mouse inner cell masses to form trophectoderm derivatives in vivoDevelopmental Biology, 1979
- Effects of complete tail bud extirpation on early development of the posterior region of the chick embryoThe Anatomical Record, 1978
- Studies on the composition and formation of mouse blastocoele fluid using electron probe microanalysisDevelopmental Biology, 1977
- Explantation of extraembryonic parts of 7-day-old mouse egg cylindersCellular and Molecular Life Sciences, 1973
- Biological Sciences: X Chromosome Inactivation studied by Injection of a Single Cell into the Mouse BlastocystNature, 1971
- Cell cycle analysis in the mouse egg-cylinderExperimental Cell Research, 1971