Dysfunctional Adiposity and the Risk of Prediabetes and Type 2 Diabetes in Obese Adults

Abstract

Quiz Ref ID A marked increase in the prevalence of overweightand obesity¹ has contributed to a doubling in type 2 diabetes mellitus incidence over the past 3 decades.² Increasing rates of diabetes among obese individuals has counterbalanced reductions in other cardiovascular disease (CVD) risk factors and is the primary factor contributing to a slowed decline in CVD event rates in the general population.³ Prediabetes, an intermediate hyperglycemia phenotype and risk factor for diabetes,⁴ is also associated with obesity and carries an excess risk for CVD and death.⁵