Familial Hyperparathyroidism

Abstract

GROWING awareness of the protean clinical manifestations of primary hyperparathyroidism has resulted in a marked increase in the number of cases diagnosed.^{1 , 2} Although hyperparathyroidism is predominantly a sporadic disease the occasional involvement of more than 1 person in a family has been recognized for many years. More recently, the occurrence of hyperparathyroidism as part of the familial polyendocrine syndromes, including the Zollinger–Ellison syndrome, has received wide attention.Mandl³ noted that a sister of the first surgically treated patient with hyperparathyroidism had localized osteitis fibrosa, but no further information was recorded. In 1936 Goldman and Smyth⁴ first reported primary hyperparathyroidism in . . .