Role of PP2Cα in cell growth, in radio- and chemosensitivity, and in tumorigenicity
Open Access
- 1 January 2007
- journal article
- Published by Springer Nature in Molecular Cancer
- Vol. 6 (1), 65
- https://doi.org/10.1186/1476-4598-6-65
Abstract
PP2Cα is the representative member of the type 2C family of protein phosphatases, and it has recently been implicated in the regulation of p53-, TGFβ-, cyclin-dependent kinase- and apoptosis-signaling. To investigate the role of PP2Cα in cell growth and in radio- and chemosensitivity, wild type and PP2Cα siRNA-expressing MCF7 cells were subjected to several different viability and cell cycle analyses, both under basal conditions and upon treatment with radio- and chemotherapy. By comparing the growth of tumors established from both types of cells, we also evaluated the involvement of PP2Cα in tumorigenesis.Keywords
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