Reversal of the Actions of Tetraethyl Pyrophosphate in Surviving Mammalian Tissue

Abstract

Effects of nicotinhydroxamic acid methiodide were studied on isolated rabbit auricles and intestinal strips treated with tetraethyl pyrophosphate (TEPP). This compound significantly reversed the TEPP induced actions in these organs. The reversal was not a result of an anti-cholinergic effect or of a direct action. A true chemical reactivation of cholinesterase is thereby indicated.