Presence of anti-Sm reactivity in autoimmune mouse strains
Open Access
- 1 February 1978
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 147 (2), 582-587
- https://doi.org/10.1084/jem.147.2.582
Abstract
In this study, the technique of double immunodiffusion (ID) in agarose standard human reference sera (of known ANA [anti-nuclear antibody] specificity) was used to survey a large number of mice from the NZB, NZB .times. NZW, MRL/1, MRL/n, BXSB and other strains. The anti-Sm marker antibody was found almost uniquely in the MRL/1 and MRL/n animals. These 2 related strains may serve as experimental models to explore the mechanism stimulating the production of this unique autoantibody in SLE [systemic lupus erythematosus].This publication has 7 references indexed in Scilit:
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