The fate of Escherichia coli O157:H7 and salmonellae as well as other potentially pathogenic bacteria resulting from fecal and other sources of contamination on red meat carcasses is a major concern. The development and validation of various decontamination procedures for red meat carcasses is not a new research area. However, recent morbidity and mortality attributable to the presence of E. coli O157:H7 in ground beef has heightened the awareness of and rekindled a sense of urgency for this research. Over the last few years various intervention processes have been developed and are being used to decontaminate red meat carcasses. Some of these processes include carcass rinses with antimicrobial compounds, steam, vacuum, and hot water. An overview of the results of several recent investigations demonstrating the effectiveness of these decontamination methods is presented.