Antiandrogen Implanted in Brain Stimulates Male Reproductive System
- 3 February 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 155 (3762), 593-595
- https://doi.org/10.1126/science.155.3762.593
Abstract
Chronic intrahypothalanic implantation of cyproterone, an antiandrogen, in male rats resulted in specific stimulation of testes, seminal vesicles, and prostates. Implantation of cholesterol-filled or empty tubes in the median eminence in controls was ineffective. We conclude that decreases in the amount of testosterone reaching specific receptors in the median eminence or in nearby regions activate a mechanism that produces increased gonadotropin secretion.This publication has 12 references indexed in Scilit:
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