Genetic Factors in Cardiac Hypertrophy
- 1 May 2004
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1015 (1), 225-237
- https://doi.org/10.1196/annals.1302.019
Abstract
Cardiac hypertrophy is an adaptive response to any cardiac insult or stress that increases hemodynamic load. Cardiac hypertrophy can exist in a state of compensation or progress to a decompensated state (i.e., heart failure) over time. It has been established through transgenic overexpression and gene ablation studies that multiple signaling pathways are involved in the induction of hypertrophy as well as its decompensation. This article reviews the role of G alpha q in the development of pressure overload hypertrophy and discusses the relationships between G alpha q and beta-adrenergic receptors, RGS proteins, and the proapoptotic factor, Nix/Bnip3L.This publication has 76 references indexed in Scilit:
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