LIVER INVOLVEMENT can be demonstrated in about 25% of cases of cystic fibrosis by careful clinical and autopsy evaluation, although jaundice is rare and hepatic function studies are usually normal.1A characteristic biliary cirrhosis with concretions becomes more common as age increases; sometimes this causes portal hypertension, requiring a shunt operation.1,2 In neonates with cystic fibrosis liver disease is not usually clinically apparent. Gross and microscopic abnormalities of the liver, the biliary tree,3and the gallbladder4have been described, but only a few instances of prolonged neonatal obstructive jaundice have been reported.2,5-7 This report describes a case of prolonged obstructive jaundice in a newborn with meconium ileus and jejunal atresia. Liver biopsy during a second operation for intestinal obstruction at 12 weeks of age showed regressing liver pathology at a time when liver disease had become clinically inapparent. Report of a Case This infant (#1354593)