Effect of Pentagastrin, Histalog, Glucagon, Secretin, and Perchlorate on the Gastric Handling of99mTc Pertechnetate in Mice

Abstract

Pentagastrin, histalog, glucagon, secretin and perchlorate were i.v. injected into mice to investigate the hormonal regulation of 99mTc pertechnetate uptake by gastric mucosa. Pentagastrin significantly increased uptake; the effect of histalog was weaker. Secretin did not alter the uptake. Glucagon produced some diminution, and perchlorate significantly inhibited gastric uptake. Hormones may play a role in improving the sensitivity and specificity of diagnostic tests for Meckel''s diverticulum.