Synthesis of Orthogonally Protected L-Homocysteine and L-2-Amino-4-phosphonobutanoic Acid from L-Homoserine

Abstract

Convenient syntheses of N-tert-butoxycarbonyl-S-p-methoxybenzyl-L-homocysteine benzyl ester and benzyl L-4-dimethylphosphono-2-N-phthalimidobutanoate from commercially available L-homoserine are described along with their incorporation into dipeptides.