Comparison of absorbable materials for surgical haemostasis
- 1 October 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 75 (10), 969-971
- https://doi.org/10.1002/bjs.1800751010
Abstract
The haemostatic effect of two new materials has been compared with surgical gauze and oxidized cellulose using a standardized liver laceration in New Zealand White rabbits. Following excision of a 3 cm2 disc of tissue from the liver, 42 rabbits were randomized to the use of gauze swabs (n = 6), oxidized cellulose (Surgicel®) (n = 12), porcine collagen (Medistat®) (n = 12) or calcium alginate (Kaltostat®) (n = 12) to control the resulting haemorrhage. Blood loss and time to haemostasis were accurately recorded. The absorbable materials were left in situ and animals killed between 2 weeks and 6 months later to examine speed of absorption and resulting adhesions. Calcium alginate stopped bleeding in 15min with gauze (P<0.001). Oxidized cellulose and calcium alginate reabsorbed within 3 months leaving a fibrous scar, but a vigorous foreign body reaction was seen with porcine collagen which caused intestinal obstruction in 5 out of 12 animals within 3 months.Keywords
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