Effects of Vitamin D and Cortisone on Intestinal Absorption of Calcium in the Rat

Abstract

Using an in vitro intestinal segment technique, intestinal active transport of Ca45 was studied in rats pretreated for 6 days with 59661-59678 DIGESTIVE SYSTEM [Vol. 36] 5694 physiologic and excessive doses of vitamin D and/or cortisone acetate. Active transport was greatest in the duodenal segment under all conditions studied. With physiologic amounts of vitamin D, active transport was confined to the duodenal segment; excessive vitamin D increased, and cortisone decreased, calcium transport. In the jejunal and ileal segments active transport occurred only with excessive vitamin D, and was not reduced by cortisone.