The Fas Death Factor
- 10 March 1995
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 267 (5203), 1449-1456
- https://doi.org/10.1126/science.7533326
Abstract
Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.Keywords
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