Effects of qinghaosu and related compounds on incorporation of [G-3H]hypoxanthine by Plasmodium falciparum in vitro
- 31 December 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 77 (4), 522-523
- https://doi.org/10.1016/0035-9203(83)90129-3
Abstract
The effects of qinghaosu (QHS), dihydroqinghaosu (DHQ), artemether and alpha-propoxycarbonyl dihydroartemisine (SM242) on incorporation of [G-3H] hypoxanthine into Plasmodium falciparum were studied in vitro. Antimalarial activity in vitro is enhanced by reduction of the keto group, since DHQ, artemether and SM242 were more than 100 times more active than QHS.Keywords
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