Mecillinam, a New Prophylactic for Travellers' Diarrhoea: A Prospective Double-blind Study in Tourists Travelling to Egypt and the Far East
- 31 May 1983
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Infectious Diseases
- Vol. 15 (2), 189-193
- https://doi.org/10.3109/inf.1983.15.issue-2.11
Abstract
The efficacy of mecillinam when given orally in preventing travellers' diarrhoea has been studied. Preliminary investigations in volunteers showed that single daily doses of up to 200 mg for 3 weeks were well tolerated. A randomised double-blind study was carried out in a group of tourists visiting Egypt and the Far East. The subjects took either mecillinam (200 mg daily) or placebo for 25 days. 19/36 tourists (53%) taking placebo and 5/38 tourists (13%) taking mecillinam developed travellers' diarrhoea during the treatment period (p<0.001). In the placebo group enterotoxigenic Escherichia coli (LT/ST) were found in 2 cases of diarrhoea and Salmonella in another 2 cases. In the remaining cases of diarrhoea the etiological agent was not found in either of the 2 groups.This publication has 14 references indexed in Scilit:
- Biweekly Prophylactic Doxycycline for Travelers' DiarrheaThe Journal of Infectious Diseases, 1981
- Modern views on travellers' diarrhoea (emporiatric enteritis)Transactions of the Royal Society of Tropical Medicine and Hygiene, 1981
- Mecillinam (Selexidin) in the treatment of neonatesjpme, 1981
- Turista among Members of the Yale Glee Club in Latin America *The American Journal of Tropical Medicine and Hygiene, 1980
- Prophylactic Doxycycline for Travelers' DiarrheaNew England Journal of Medicine, 1978
- Travelers' Diarrhea in MexicoNew England Journal of Medicine, 1976
- Travelers' Diarrhea and ToxigenicEscherichia coliNew England Journal of Medicine, 1975
- Pharmacokinetic Studies with Mecillinam and PivmecillinamChemotherapy, 1975
- Test for Escherichia coli Enterotoxin Using Infant Mice: Application in a Study of Diarrhea in Children in HonoluluThe Journal of Infectious Diseases, 1972
- Pathogenesis ofEscherichia coliDiarrheaNew England Journal of Medicine, 1971