Propagation of Hog Cholera Virus in Rabbits

Abstract

Hog cholera virus has been carried for 12 consecutive passages in rabbits by using infected rabbit spleen as transfer material. Starting from the 8th rabbit spleen passage, the virus was passed back to a pig for one passage and was then carried for 8 further passages in rabbits by using infected rabbit blood as transfer material. Aside from a febrile response, no other symptoms were observed in inoculated rabbits.