Pyruvate oxidation in pigeon brain catalyzed by fumarate
- 1 January 1946
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 40 (2), 278-283
- https://doi.org/10.1042/bj0400278
Abstract
Fumarate stimulated O2 uptake of dialyzed pigeon brain suspensions respiring in pyruvate, only when PO4- and adenine nucleotide were also present. The O2/pyruvate ratio approached 2.50, the pyruvate being oxidized completely to CO2 and water. The rate of disappearance of pyruvate was slightly decreased due to oxidation of fumarate to pyruvate, and not due to any effect on rate of utilization of pyruvate but on some intermediary product arising during pyruvate oxidation.Keywords
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