Inherited Polymorphism of Guinea Pig Factor B and C4: Evidence for Genetic Linkage between the C4 and Bf Loci
- 1 May 1977
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 118 (5), 1822-1826
- https://doi.org/10.4049/jimmunol.118.5.1822
Abstract
An inherited structural polymorphism of the guinea pig complement protein C4 and of factor B of the alternative pathway was demonstrated by use of high voltage agarose electrophoresis combined with a subsequent immunofixation technique. No polymorphism of guinea pig C3 could be shown. Three common allelic genes were proven to code for C4-S, C4-Sl, and C4-F, respectively. Two common allelic genes are responsible for the Bf-F and Bf-S phenotype expression. A strong linkage disequilibrium between both C4 and Bf was demonstrated.This publication has 5 references indexed in Scilit:
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