The development and biology of bradyzoites of toxoplasma gondii
- 1 January 2000
- journal article
- review article
- Published by IMR Press in Frontiers in Bioscience-Landmark
- Vol. 5 (1), d391-405
- https://doi.org/10.2741/weiss
Abstract
Toxoplasma gondii is a protozoan parasite of mammals and birds that is an important human pathogen. Infection with this Apicomplexan parasite results in its dissemination throughout its host via the tachyzoite life-stage. After dissemination these tachyzoites differentiate into bradyzoites within cysts that remain latent. These bradyzoites can transform back into tachyzoites and in immunosupressed individuals this often results in symptomatic disease. Both tachyzoites and bradyzoites develop in tissue culture and thus this crucial differentiation event can be studied. Recent advances in the genetic manipulation of T. gondii have expanded the molecular tools that can be applied to studies on bradyzoite differentiation. Evidence is accumulating that this differentiation event is stress mediated and may share common pathways with other stress-induced differentiation events in other eukaryotic organisms. Study of the stress response and signaling pathways are areas of active research in this organism. In addition, characterization of unique bradyzoite-specific structures, such as the cyst wall, should lead to a further understanding of T. gondii biology. This review focuses on the biology and development of bradyzoites and current approaches to the study of the tachyzoite to bradyzoite differentiation process.Keywords
This publication has 88 references indexed in Scilit:
- Cyst formation by Toxoplasma gondii in vivo and in brain-cell culture: a comparative morphology and immunocytochemistry studyZeitschrift Fur Parasitenkunde-Parasitology Research, 1997
- Host cells of Toxoplasma gondii encystation in infected primary culture from mouse brainZeitschrift Fur Parasitenkunde-Parasitology Research, 1997
- Escherichia coli β-galactosidase as an in vitro and in vivo reporter enzyme and stable transfection marker in the intracellular protozoan parasite Toxoplasma gondiiGene, 1996
- Toxoplasma gondii: Reactivity of murine sera against tachyzoite and cyst antigens via FAST-ELISAInternational Journal for Parasitology, 1995
- Immunogenetics influence outcome of Toxoplasma gondii infectionResearch in Immunology, 1993
- Virulent strains of Toxoplasma gondii comprise a single clonal lineageNature, 1992
- An overview of the problem of toxoplasmosis and pneumocystosis in AIDS in the USA: Implication for future therapeutic trialsEuropean Journal of Clinical Microbiology & Infectious Diseases, 1991
- Role of gamma interferon inToxoplasma gondii infectionEuropean Journal of Clinical Microbiology & Infectious Diseases, 1991
- Tissue cyst rupture in mice chronically infected withToxoplasma gondiiZeitschrift Fur Parasitenkunde-Parasitology Research, 1989
- Feinstruktur der Cyste und Cystenwand von Sarcocystis tenella, Besnoitia jellisoni, Frenkelia sp. und Toxoplasma gondiiThe Journal of Protozoology, 1974