Effect of Sensitization to BSA on Adjuvant Disease in Normal and Neonatally Thymectomized Rats.

Abstract

Summary Adjuvant arthritis is suppressed in sham-operated rats sensitized with adjuvant mixtures containing BSA. In neonatally thymectomized rats, in whom sensitization to BSA fails to occur, there is a moderate reduction in the intensity of the arthritis observed. In similar animals given lymph node cells at or just after the time of sensitization, the response to BSA is normal; yet the arthritis response is like that in animals not receiving cells.