Effect of a Sulfated Mucopolysaccharide (ROl-8307) on the Zona Glomerulosa of the Rat Adrenal Gland
- 1 March 1966
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 78 (3), 651-654
- https://doi.org/10.1210/endo-78-3-651
Abstract
R01-8307 (N-formyl-chitosan polysulfuric acid), a sulfated mucopolysaccharide with low anticoagulant activity, has been shown, in a dose of 80 mg/kg, to produce marked reduction in the width of the zona glomerulosa of the rat adrenal gland without apparent effect on the other zones. This selective effect of R01-8307 suggests that the compound may be a useful tool in the study of adreno-cortical function.This publication has 4 references indexed in Scilit:
- Suppression of Plasma Renin Activity in Primary AldosteronismJAMA, 1964
- Effect of Heparin and Heparinoids on the Synthesis of Aldosterone and Corticosterone by the Rat Adrenal GlandEndocrinology, 1964
- The Natriuretic and Aldosterone-Suppressive Action of Heparin and Some Related Polysulfated Polysaccharides1Journal of Clinical Endocrinology & Metabolism, 1964
- Excretion pattern and mechanism of diuresis induced by heparinClinica Chimica Acta; International Journal of Clinical Chemistry, 1960