ADENYLATE CYCLASE ACTIVITY IN THE UTERINE CERVIX OF NEONATAL AND IMMATURE MICE: INFLUENCE OF OESTRADIOL-17β
- 1 February 1980
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 84 (2), 255-260
- https://doi.org/10.1677/joe.0.0840255
Abstract
The influence of long-term oestradiol stimulation on adenylate cyclase activity was investigated in homogenates from uterine cervices of neonatal (3-day-old) and immature (14-day-old) NMRI mice. A significant increase of enzyme activity, measured in the presence of fluoride ions (NaF), after oestradiol treatment was found in preparations from neonatal but not from those of immature female mice; this was irrespective of whether the enzyme activity was related to wet weight, amount of protein or DNA content. The enzyme activity was stimulated in vitro by NaF and 5-guanylylimidodiphosphate while isoprenalin, histamine, prolactin and oestradiol had no effect. These results indicated an age-related difference in the effects of oestradiol in the uterine cervix of the mouse.This publication has 6 references indexed in Scilit:
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