Bradykinin analogues: differential agonist and antagonist activities suggesting multiple receptors
Open Access
- 30 April 1988
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 94 (1), 3-5
- https://doi.org/10.1111/j.1476-5381.1988.tb11492.x
Abstract
Bradykinin analogues with specific antagonist activity in several bioassays were evaluated for effects on [3H]-bradykinin receptor binding sites and inositol phosphate production in neuroblastoma N1E-115 cells. The analogues varied in their affinities for bradykinin receptors in guinea-pig ileum and N1E-115 cell membranes, in their effects on uterine and ileal contractions and in their agonist or antagonist activity on phosphoinositide turnover in N1E-115 cells. These tissue specific effects suggest the presence of multiple bradykinin receptor subtypes.This publication has 9 references indexed in Scilit:
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