The effect of noradrenaline, injected into the hypothalamus, on thermoregulation in the cat.
Open Access
- 1 September 1976
- journal article
- research article
- Published by Wiley in The Journal of Physiology
- Vol. 261 (1), 211-222
- https://doi.org/10.1113/jphysiol.1976.sp011554
Abstract
1. Noradrenaline (NA) was microinjected into the anterior hypothalamic/preoptic area(AH/POA) of unanaesthetized cats held at ambient temperatures of 10, 22 or 35 degrees C. Loci in which injection of NA caused body temperature changes were also found to be sensitive to the febrile action of PGE1. 2. At all ambient temperatures, NA caused a dose‐dependent fall in body temperature. However the mechanisms by which these temperature changes were brought about varied at different ambient temperatures. In cats maintained at the higher ambient temperature, NA activated heat loss mechanisms whereas in the cats maintained in the 10degrees C environment, the major effect of NA injection was an inhibition of heat conservation and heat production mechanisms. 3. We conclude that NA acts in cats not only as an inhibitor of heat conservation and production, but also acts in an excitatory manner on an active heat loss pathway within the AH/POA.This publication has 20 references indexed in Scilit:
- Absence of fever in the rabbit following intrahypothalamic injections of noradrenaline into PGE1-sensitive sitesNeuropharmacology, 1976
- Body temperature responses at different ambient temperatures following injections of prostaglandin E1 and noradrenaline into the brainPharmacology Biochemistry and Behavior, 1976
- 5-HT- and norepinephrine-induced release of ACh from the thalamus and mesencephalon of the monkey during thermoregulationBrain Research, 1975
- Central alpha adrenergic receptors in thermoregulationNeuropharmacology, 1972
- Fever produced by prostaglandin E1The Journal of Physiology, 1971
- An improved push-pull cannula system for perfusing an isolated region of the brainPhysiology & Behavior, 1970
- Changes in temperature produced by micro‐injections of amines into the anterior hypothalamus of catsThe Journal of Physiology, 1965
- Effects on temperature of amines injected into the cerebral ventricles. A new concept of temperature regulationThe Journal of Physiology, 1964
- A New Concept of Temperature Regulation by Amines in the HypothalamusNature, 1963
- A Method for the Combined Staining of Cells and Fibers in the Nervous SystemJournal of Neuropathology and Experimental Neurology, 1953