Reduced Number of Peripheral Blood Granulocytic Progenitor Cells in Patients with Down's Syndrome
- 1 July 1979
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 42 (3), 417-423
- https://doi.org/10.1111/j.1365-2141.1979.tb01150.x
Abstract
The number of granulocytic progenitor cells (colony forming units in culture: CFUc) in the blood of patients with Down''s syndrome was reduced by 73.2% when compared to age and sex matched controls. The blood CFUc of the Down''s syndrome patients and the controls showed similar sensitivity to hydroxyurea [in vitro] suggesting that the low number of progenitor cells in Down''s syndrome was not compensated by a marked increase in their cellular proliferation. The colony size distributions were similar for the patients and the controls and repeated assays at various intervals revealed no marked fluctuation in the number of blood CFUc in either group. The significance of the reduced number of circulating CFUc in Down''s syndrome in relation to the known susceptibility of such patients to leukemia was discussed.This publication has 23 references indexed in Scilit:
- Cell Production and Cell Function in Human Cyclic NeutropeniaScandinavian Journal of Haematology, 2009
- Leukocyte function in Down's syndrome quantitative NBT reduction and bactericidal capacityClinical Immunology and Immunopathology, 1974
- DOWN'S SYNDROME AND LEUKÆMIAThe Lancet, 1972
- Down's syndrome and acute leukemia: Myeloblastic or lymphoblastic?: Report of forty-three cases and review of the literatureAmerican Journal Of Medicine, 1972
- Human bone marrow colony growth in agar‐gelJournal of Cellular Physiology, 1970
- Down's syndrome: Variation of leukemia occurrence in institutionalized populationsJournal of Chronic Diseases, 1968
- LEUCOCYTE ENZYMES IN DOWN'S SYNDROMEThe Lancet, 1964
- LEUCOCYTE ENZYMES IN DOWN'S SYNDROMEThe Lancet, 1964
- Frequency of Drumsticks in Normal Women and in Patients with Chromosomal AbnormalitiesNature, 1964
- The Differential Leucocyte Count in MongolsJournal of Mental Science, 1949